Designation: Post-doctoral Fellow (PDF)
Research Area: G-quadruplex biology and therapeutics
Location: Aparicio Laboratory | Department of Pathology and Laboratory Medicine | Faculty of Medicine (Samuel Aparicio), BC Cancer Research Center, Vancouver, British Columbia, Canada
Eligibility/Qualification: The ideal candidate should have a Ph.D. in molecular biology or a related field with a background in DNA drug target biology in cancer. Strong leadership ability and expertise in molecular biology, single cell genomics and transcriptomics are essential. Experience with bioinformatics approaches to biological data and familiarity with handling genomics data are desirable.
Posting End Date: April 17, 2023
Job Description:
The Aparicio Laboratory is seeking a highly motivated Postdoctoral Research Fellow (PDF) with strong leadership ability and expertise in molecular biology, single cell genomics and transcriptomics, and a background in DNA drug target biology in cancer to work full-time under the supervision of Dr. Samuel Aparicio. The successful applicant will work on an exciting international project to define additional mechanisms and target engagement of G4 ligands in cancer genomes, utilizing single-cell sequencing and chemical biology methods.
The Aparicio lab is developing small molecule ligands of G-quadruplex structures in DNA as a therapeutic, based on recent success from the lab demonstrating for the first time clinical proof of principle (Hilton et al, Nat. Comms 2022) for a G4 binder. The post holder will also have the opportunity to interact as part of the international Welcome LEAP Delta Tissue project and an exciting new program in the biology of epithelium from high-risk carriers of BRCA1/BRCA2 mutations.
The PDF will provide leadership, strategic direction, and translational research pertaining to single-cell genomics and transcriptomics, and CRISPR methods. The successful candidate will design and implement a research plan to investigate the clonal dynamics in human cancer through single-cell methods. They will also design and conduct animal experiments, conduct in vivo testing or characterization of drugs, small molecules, knockouts or antibodies in relevant PDX animal models, foster research collaborations, and work jointly with academic, clinical, industry, and other partners.
The PDF will be accountable for the quality and integrity of the research and data, including analyses and interpretation, as well as the effective and efficient management of research projects and deliverables. The position requires innovation, strategic planning, and adaptability.
Key Responsibilities:
- Provide leadership, strategic direction, and translational research pertaining to single-cell genomics and transcriptomics, and CRISPR methods.
- Design and implement research plan to investigate the clonal dynamics in human cancer through single-cell methods.
- Design and conduct animal experiments.
- Conduct in vivo testing or characterization of drugs, small molecules, knockouts, or antibodies in relevant PDX animal models.
- Foster research collaborations and work jointly with academic, clinical, industry, and other partners.
- Scientifically document lab experiments, data analysis, interpretations.
- Write manuscripts, present results at internal and external meetings.
- Identify funding opportunities and if required write or assist with grant proposals.
- Lead and mentor junior trainees/students in the laboratory.
How to Apply:
To apply, please send a cover letter, curriculum vitae, and the names and contact information of three referees to Dr. Samuel Aparicio (saparicio@bccrc.ca) with the subject line “PDF Application: G-quadruplex Biology and Therapeutics”. The position start date is flexible, and applications will be accepted until 11:59 PM on the day prior to the Posting End Date
