Scholarship Opportunity: Nucleocytoplasmic Shuttling: A prestigious research position is available at the International Institute of Molecular and Cell Biology in Warsaw (IIMCB) in the Laboratory of Cellular Proteostasis. The project focuses on identifying factors and pathways that regulate the nucleocytoplasmic shuttling of VCP/p97, a key protein in maintaining cellular proteostasis. This research aims to expand the understanding of VCP biology and its implications in neurodegenerative diseases.
Scholarship Opportunity: Investigating Factors Regulating VCP/p97 Nucleocytoplasmic Shuttling
Designation:
Researcher (PhD Candidate/Postdoctoral Fellow)
Research Area:
Molecular Biology, Cell Biology, Biochemistry, Neuroscience
Location:
International Institute of Molecular and Cell Biology in Warsaw, Poland
Eligibility/Qualification:
- MSc degree in biology, biochemistry, or a related field.
- Solid knowledge in at least one of the following disciplines: molecular biology, biochemistry, cell biology, neuroscience.
- Understanding of mechanisms important for cellular proteostasis.
- Basic hands-on experience in molecular biology, cell biology, or fluorescent microscopy.
- Prior experience with human induced pluripotent stem cell (iPSC)-derived neurons is advantageous but not required.
- Interest in cellular proteostasis and neurodegeneration.
- Written and spoken fluency in English.
- Willingness to learn, take on new challenges, and work independently with analytical thinking.
- Good interpersonal skills and a collaborative attitude.
Job Description:
The successful candidate will work on a cutting-edge research project that investigates the regulation of VCP/p97 nucleocytoplasmic shuttling. Using advanced techniques such as CRISPR/Cas9-based high-throughput screening, state-of-the-art microscopy, and biochemical methods, the research will identify and characterize novel factors and pathways that control VCP movement between the cytosol and nucleus. The study will utilize various cellular models, including human iPSC-derived neurons, to provide insights into VCP function and potential therapeutic solutions for diseases caused by VCP mutations, such as multisystem proteinopathy and frontotemporal dementia.
How to Apply:
Interested candidates should submit their CV, a cover letter detailing their research experience and interests, and contact information for at least two references to Dr. Lidia Wrobel at lwrobel@iimcb.gov.pl.
Last Date for Application:
Until position filled
