Postdoc Position in Clinical Immunopeptidomics and Proteomics, Utrecht University, Netharlands

Summary

Utrecht University is seeking a highly motivated and experienced Postdoctoral Researcher to join the Biomolecular Mass Spectrometry and Proteomics division within the Department of Pharmaceutical Sciences. The researcher will work in the team led by Dr. Fabio Marino, focusing on the discovery, quantification, and validation of disease-associated antigens for cancer immunotherapy and translational medicine using advanced mass spectrometry workflows.

Designation

Postdoctoral Researcher (Postdoc)

Key Information Overview

Research Area

• Biomolecular Mass Spectrometry & Proteomics
• Clinical Immunopeptidomics & Proteogenomics
• Cancer Immunotherapy & Antigen Discovery (HLA Class I/II)
• Translational & Precision Medicine

Location

Utrecht University, Faculty of Science, Utrecht, The Netherlands.

Eligibility / Qualification

Required Qualifications & Experience:

• Education: A PhD in Proteomics, Analytical Chemistry, Biochemistry, or a closely related field.
• Technical Experience: Proven hands-on experience in mass spectrometry–based proteomics and/or immunopeptidomics within clinical or translational research settings.
• Methodological Expertise: Demonstrated expertise in Data-Independent Acquisition (DIA), Parallel Reaction Monitoring (PRM), quantitative proteomics workflows, data normalization, and quality control strategies.
• Data Processing: Strong experience in processing and interpreting complex MS datasets.
• Scientific Output: A proven track record of peer-reviewed publications in relevant fields.
• Soft Skills: Excellent communication, multidisciplinary collaboration, and teamwork skills.

Preferred Qualifications:

• Experience in structural biology and cross-linking mass spectrometry (XL-MS).
• Familiarity with workflow automation and reproducible data analysis pipelines.

Job Description

As a Postdoctoral Researcher, you will play a central role in advancing state-of-the-art immunopeptidomics and proteomics workflows to identify, quantify, and validate clinically relevant targets for cancer immunotherapy and vaccine development.

Key Responsibilities:

• Design and execute mass spectrometry–based workflows for the identification and quantification of disease-associated antigens from clinical specimens.
• Develop, optimize, and implement DIA- and PRM-based proteomics methods.
• Perform quantitative data analysis, normalization, quality control, and statistical interpretation on proteomics datasets.
• Contribute to biomarker and antigen validation studies across diverse clinical cohorts.
• Collaborate closely with multidisciplinary partners including clinicians, computational biologists, translational researchers, and industrial partners (including Princess Máxima Center and Oncode Accelerator).
• Drive method development, data interpretation, scientific manuscript preparation, and grant writing.

How to Apply

Interested candidates must submit their application online via the official Utrecht University job portal using the “Apply now” button on the vacancy page.

Required Application Documents:

1. A Letter of Motivation
2. An up-to-date Curriculum Vitae (CV)
3. Contact details (names, phone numbers, and email addresses) of at least two academic/professional references

• Contact for position details: Dr. Celine Miedema at t.c.miedema@uu.nl
• Contact for procedural queries: science.recruitment@uu.nl

Last Date for Apply

31 August 2026 (Applications are reviewed on a rolling basis; the position may close earlier if a suitable candidate is selected).

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