Summary
The Sethi Laboratory at Dana-Farber Cancer Institute and Harvard Medical School is seeking an exceptional postdoctoral fellow in computational cancer biology, single-cell genomics, epigenomics, and spatial biology. The incoming fellow will join a highly collaborative program with substantial existing datasets, experimental systems, and senior scientific expertise, with a planned period of overlap with experienced lab members to facilitate knowledge transfer. This role offers significant freedom to establish new research questions and approaches within the lab’s focus on gastrointestinal cancer evolution.
Designation
Research Fellow
Research Area
- Computational Cancer Biology
- Single-Cell Genomics
- Epigenomics
- Spatial Biology
- Gastrointestinal Cancer Evolution
- Cell-state Plasticity (cancer initiation, progression, therapeutic resistance)
Location
450 Brookline Ave, BOSTON, MA 02215, USA
Eligibility/Qualification
Education
- Ph.D., M.D., or M.D./Ph.D.
Experience/Skills
- Expertise in quantitative or computational biology.
- Relevant backgrounds include computational biology, bioinformatics, genomics, statistics, computer science, systems biology, or cancer biology.
- Experience with one or more of the following:
- Single-cell RNA-seq and/or single-cell ATAC-seq
- Epigenomic analysis and chromatin biology
- Spatial transcriptomics or other spatial-omics approaches
- Multimodal data integration
- Computational analysis of longitudinal or perturbational experiments
- Strong intellectual curiosity.
Job Description
The Research Fellow will be an integral part of the Sethi Laboratory, focusing on understanding cell-state plasticity in gastrointestinal cancer. Key responsibilities include:
- Independently formulating research questions.
- Developing and executing complex computational analyses.
- Collaborating closely with experimental scientists.
- Interpreting genomic datasets.
- Presenting research findings internally and externally.
- Contributing to the preparation of manuscripts and grant applications.
- Mentoring junior trainees within the lab.
The lab utilizes human samples, patient-derived models, genetically engineered mouse models, organoids, functional genomics, epigenomics, and computational biology to investigate:
- How aberrant developmental and oncofetal cell states are established during premalignant cancer initiation.
- How metabolic and environmental exposures create durable epigenetic memories that alter future cancer behavior.
- How established cancers exploit cellular plasticity to evade targeted therapies.
Salary/Pay Rate
$72,000.00 – $76,385.00 per year
How to Apply
Interested candidates should apply through the official Dana-Farber Cancer Institute careers portal.
Last Date for Apply
Until position filled
Apply Link
Apply for Research Fellow-Sethi Lab
