PhD Position in Antigen Presentation: The Université Paris-Saclay is offering a PhD position focused on studying the role of selective autophagy receptors (SARs) in antiviral immunity, specifically in the presentation of antigens. This position is part of an ANR-funded project and will be supervised by Dr. Arnaud Moris at the Institut de Biologie Intégrative de la Cellule (I2BC).
PhD Position: Selective Autophagy Receptors in Antigen Presentation
Designation:
PhD Student
Research Area:
Immunology, Virology, Cell Biology, Antigen Presentation, Autophagy, Host-Pathogen Interactions
Location:
Université Paris-Saclay, I2BC, Paris, France
Eligibility/Qualification:
- Master’s degree in a relevant field (Immunology, Virology, Cell Biology)
- Strong background in host-pathogen interactions and cellular biology
- Experience in immunology and virology laboratory techniques
- Knowledge of autophagy is a plus
- Motivated to develop an innovative project in immunology and infectious diseases
- Ability to adapt quickly to new environments and demonstrate initiative in collaborative settings
Job Description:
The PhD candidate will investigate the role of the selective autophagy receptor TAX1BP1 and other SARs in antigen presentation pathways. Key tasks include:
- Characterizing the regulation of innate signaling and antigen presentation by TAX1BP1
- Using viral proteins to define pathways and molecular mechanisms of SAR functions
- Applying immunopeptidomics, imaging, and biochemical approaches to study the role of SARs in antigen processing and MHC-II molecule trafficking
- Participating in weekly meetings, presenting research findings, and collaborating with team members and external partners
The project will be divided into three complementary tasks:
- Influence of viral proteins on the peptide repertoire presented by MHC-II molecules
- Regulation of MHC-II molecule trafficking by SARs
- Impact of SARs on MHC-II-restricted antigen processing routes
How to Apply:
Interested candidates should submit the following documents:
- Curriculum Vitae
- Cover Letter explaining research interests and motivation
- Contact information for at least two references
Applications should be sent to Dr. Arnaud Moris at [email contact] with the subject line “PhD Application – Autophagy Receptors in Antigen Presentation”.
Last Date for Apply:
August 11, 2024, by 23:59 (CET)
Additional Information:
- Start Date: October 1, 2024
- The candidate will be integrated into the “Autophagy and Antiviral Immunity” team and will have access to state-of-the-art facilities and training at I2BC.
- The position is fully funded by the ANR program SARDINN.
For more details, please visit the I2BC team website.
