PhD Position in Antigen Presentation, I2BC, Paris, France

Postdoc in France
PhD Position in Antigen Presentation: The Université Paris-Saclay is offering a PhD position focused on studying the role of selective autophagy receptors (SARs) in antiviral immunity, specifically in the presentation of antigens. This position is part of an ANR-funded project and will be supervised by Dr. Arnaud Moris at the Institut de Biologie Intégrative de la Cellule (I2BC).

PhD Position: Selective Autophagy Receptors in Antigen Presentation


PhD Student

Research Area:

Immunology, Virology, Cell Biology, Antigen Presentation, Autophagy, Host-Pathogen Interactions


Université Paris-Saclay, I2BC, Paris, France


  • Master’s degree in a relevant field (Immunology, Virology, Cell Biology)
  • Strong background in host-pathogen interactions and cellular biology
  • Experience in immunology and virology laboratory techniques
  • Knowledge of autophagy is a plus
  • Motivated to develop an innovative project in immunology and infectious diseases
  • Ability to adapt quickly to new environments and demonstrate initiative in collaborative settings

Job Description:

The PhD candidate will investigate the role of the selective autophagy receptor TAX1BP1 and other SARs in antigen presentation pathways. Key tasks include:

  • Characterizing the regulation of innate signaling and antigen presentation by TAX1BP1
  • Using viral proteins to define pathways and molecular mechanisms of SAR functions
  • Applying immunopeptidomics, imaging, and biochemical approaches to study the role of SARs in antigen processing and MHC-II molecule trafficking
  • Participating in weekly meetings, presenting research findings, and collaborating with team members and external partners

The project will be divided into three complementary tasks:

  1. Influence of viral proteins on the peptide repertoire presented by MHC-II molecules
  2. Regulation of MHC-II molecule trafficking by SARs
  3. Impact of SARs on MHC-II-restricted antigen processing routes

How to Apply:

Interested candidates should submit the following documents:

  • Curriculum Vitae
  • Cover Letter explaining research interests and motivation
  • Contact information for at least two references

Applications should be sent to Dr. Arnaud Moris at [email contact] with the subject line “PhD Application – Autophagy Receptors in Antigen Presentation”.

Last Date for Apply:

August 11, 2024, by 23:59 (CET)

Additional Information:

  • Start Date: October 1, 2024
  • The candidate will be integrated into the “Autophagy and Antiviral Immunity” team and will have access to state-of-the-art facilities and training at I2BC.
  • The position is fully funded by the ANR program SARDINN.

For more details, please visit the I2BC team website.



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