PhD Studentship in Rare Kidney Disease, Newcastle University, UK

Summary

This PhD studentship focuses on Nephronophthisis (NPHP), a severe autosomal recessive kidney disease that leads to progressive renal failure. The study investigates the efficacy of nonsense read-through drugs to develop potential disease-modifying therapies.

PhD Studentship in Rare Kidney Disease, Newcastle University, UK

Designation

PhD Studentship

Research Area

• Rare Kidney Disease
• Nephronophthisis
• Molecular Biology and Human Genetics

Location

Newcastle University, UK

Eligibility/Qualification

• Hold or expect to achieve at least a 2:1 honors degree or equivalent in a relevant subject (human genetics or molecular biology).
• Additional qualifications such as an MRes are advantageous.
• Open to home and international applicants; international candidates must cover the difference between home and international fees.
• English Language Requirement: IELTS 6.5 overall, with no sub-skill below 5.5.

Job Description

The focus of the research will be on:

• Deep phenotyping of urine-derived renal epithelial cells (URECs) from NPHP patients.
• Evaluating the response to novel nonsense read-through compounds.
• Characterizing primary ciliary phenotypes in URECs with nonsense mutations.
• Utilizing a Cep290 animal model for in vivo studies.

How to Apply

1. Visit the University’s Application Portal: Newcastle University Application Portal.
2. In the ‘Course choice’ tab, select:

• Type of Study: Postgraduate Research
• Mode of Study: Full Time
• Year of Entry: 2026
• Course code: ‘8420F’

1. Select ‘PhD Biosciences (FT)’ and save selection.
2. Upload the following:

• Personal Statement
• Covering letter & CV detailing your interests and experience
• Degree transcripts/certificates
• English language qualification (if applicable)

1. Use the Studentship Reference code ‘BI105’ in your application.

Last Date for Apply

9th June 2026

For further inquiries, please contact John Sayer at john.sayer@newcastle.ac.uk.

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