Summary
The Biozentrum of the University of Basel invites applications for a fully funded PhD position in the research group of Prof. Marek Basler. The project focuses on unraveling the molecular mechanisms that control the assembly, precise spatial localization, timing, and function of the bacterial Type 6 Secretion System (T6SS).
Overview
| Feature | Details |
| Position Title | PhD Student – Function and Regulation of Type 6 Secretion System |
| Host Institution | Biozentrum, University of Basel |
| Research Group | Prof. Marek Basler Lab |
| Funding Type | Fully Funded |
| Start Date | Starting immediately or by mutual agreement |
| Application Mode | Online Application Form |
| Application Deadline | Review begins September; open until filled |
Subject Area
- Molecular Microbiology
- Protein Biochemistry & Protein-Protein Interactions
- Bacterial Cell Biology & Signaling
- Live-Cell Imaging & Electron Microscopy
Location
- City/Country: Basel, Switzerland
- Institution: Biozentrum, University of Basel
Eligibility Criteria
- Academic Qualifications: An MSc degree (completed or near completion) with a research thesis in molecular microbiology, protein biochemistry, protein-protein interactions, electron microscopy, bacterial signaling, or a related discipline.
- Desirable Experience: Prior hands-on experience with live-cell super-resolution imaging or biophysical techniques is considered an advantage.
- Language Proficiency: Strong working proficiency in English.
Scholarship & Project Description
The Project
The bacterial Type 6 secretion system (T6SS) is a dynamic nanomachine sharing evolutionary origins with contractile phage tails, enabling bacteria to deliver folded effector proteins across membranes into target cells. While recent work has revealed dynamic spatial positioning, tit-for-tat responses, and host-cell interactions, fundamental mechanistic understanding remains incomplete regarding:
- How precise timing and subcellular spatial localization of T6SS assembly are achieved.
- The specific triggers and signaling cascades activating T6SS firing.
What is Offered
- Funding: A fully funded PhD appointment within an international and multidisciplinary research group.
- Training & Development: Structured PhD program offering extensive networking, transferable skills training, and scientific exchange.
- Research Infrastructure: Direct access to state-of-the-art Biozentrum Core Facilities (Imaging, Biophysics, Electron Microscopy).
- Living Environment: High quality of life in Basel, located at the border of Switzerland, France, and Germany.
How to Apply
Applications must be submitted exclusively via the Biozentrum BIPED Online Portal.
Required Application Materials:
- Curriculum Vitae (CV): Comprehensive CV in PDF format.
- Statement of Purpose: Brief statement detailing previous research experience and specific motivation for joining the Basler Lab.
- Academic Records: Copies of degree certificates and official transcripts/mark sheets (with converted Swiss grades where applicable).
- Academic References: Contact details (names and institutional emails) for 2 to 3 academic referees.
- Language/Standardized Test Scores: Optional (e.g., TOEFL/GRE).
Informal Inquiries: Contact Prof. Marek Basler via email at
marek.basler@unibas.ch.
Last Date
until the position is filled.
