2 PhD Positions: UMCG is seeking highly motivated individuals to join our research team for two PhD positions focused on investigating epigenetic deregulation in acute myeloid leukemia (AML). The research will center on understanding the oncogenic effects of BCOR/L1 loss-of-function mutations in healthy hematopoietic stem cells and their paradoxical oncogenic properties in established AML cells. These positions are funded by the Dutch Cancer Society and offer an exciting opportunity to contribute to cutting-edge research in the Department of Experimental Hematology.
Designation: PhD Researcher
Research Area: Epigenetic deregulation in acute myeloid leukemia (AML), with a focus on BCOR and BCORL1 mutations.
Location: Department of Experimental Hematology, University Medical Center Groningen (UMCG), Netherlands.
- Master’s degree (MSc) in a biomedical or life sciences-related field.
- Proficient in English with excellent writing and presentation skills.
- Strong team player with the ability to work independently.
- Experience in cell biological techniques (eukaryotic tissue culture) is required.
- Familiarity with epigenetic techniques and NGS data processing is advantageous.
- Willingness to generate mouse models if necessary.
- Compliance with UMCG’s preventive Hepatitis B policy may be required.
- Certain positions may require a ‘Certificate of Good Conduct.’
PhD Positions on Epigenetic Deregulation in Acute Myeloid Leukemia
As a PhD researcher, you will investigate the role of BCOR and BCORL1 mutations in AML, specifically focusing on their impact on healthy hematopoietic stem cells and established AML cells. Your responsibilities will include:
- Performing CRISPR-Cas gene editing in primary hematopoietic cells.
- Conducting detailed molecular analyses of affected molecular pathways.
- Carrying out screening of in vivo effects using xenograft mouse models.
Working Environment: The Department of Experimental Hematology at UMCG is dedicated to understanding how epigenetic regulators influence cell fate decisions in healthy blood stem cells and the development of leukemia. This research is supported by the Dutch Cancer Society, offering a dynamic and collaborative environment for ambitious researchers.
What We Offer:
- Full-time (36 hours per week) contract for 1 year, extendable for an additional 3 years after evaluation.
- Starting salary of €2.789 gross per month, increasing to €3.536 gross per month (scale PRO) in the final (4th) year, based on a full-time appointment.
- Additional benefits include 8% holiday pay and an 8.3% end-of-year bonus.
- Employment conditions follow the Collective Labour Agreement for Medical Centres (CAO-UMC).
Application Deadline: October 3, 2023
How to Apply: Interested candidates are invited to apply using the digital application form available at the bottom of this page. Only applications submitted through this form will be considered.
Contact Information: For any inquiries about the position, please contact: Dr. Vincent van den Boom, Senior Scientist Email: [Provide email address] Phone: +31 50 361 1244