PhD in Cardiovascular Development: Join a cutting-edge PhD project at the University of East Anglia (UEA) focusing on the genomic control of cardiovascular development. This research will utilize advanced single-cell multi-omic approaches to explore enhancer landscapes in the chick embryo, contributing to our understanding of congenital heart and vascular defects.
Designation
PhD Candidate
Research Area
Understanding Rules of Life
Location
University of East Anglia (UEA) and Earlham Institute, Norwich, UK
Eligibility/Qualification
- A degree in biology, genetics, or a related field.
- Experience in molecular biology, bioinformatics, or developmental biology is a plus.
- Strong interest in cardiovascular research and genomic studies.
Job Description
The PhD project involves applying single-cell RNA sequencing (scRNA-seq) and single-cell ATAC sequencing (scATAC-seq) to map enhancer landscapes during early cardiovascular development. Responsibilities include:
- Integrating gene expression and chromatin accessibility data.
- Predicting active enhancers and reconstructing gene regulatory networks.
- Cloning candidate enhancers into fluorescent reporter constructs for live imaging.
- Conducting CRISPR-based perturbations to test enhancer functions in vivo.
- Collaborating with a multidisciplinary team to achieve fundamental discoveries in the field.
How to Apply
Interested candidates should send their applications to:
- Email: a.munsterberg@uea.ac.uk or g.mok@uea.ac.uk
Last Date for Apply
2nd December 2025
For more detailed information about the project and requirements, please reach out via the provided contact emails.
