Two Post-doctoral Positions at LyOS and CRCL, Lyon, France

Two Post-doctoral positions at LyOS and CRCL, Lyon, France

Designation/Position- Two Post-doctoral Positions

LyOS and CRCL, Lyon, France invites application for Two Post-doctoral Positions from eligible and interested candidates

About- Two junior post-doctoral positions are open to work on an innovative joint research program between LyOS and CRCL in Lyon, France. The program aims to investigate the translational control mediated by tumour-derived non-coding RNAs on the nesting of disseminated tumour cells in the bone marrow. The successful applicants will study the functions of tumour-derived microRNAs/snoRNAs that are specifically associated with breast cancer bone metastasis and examine the role of their translationnally regulated mRNA targets involved in preparing the pre-metastatic niche. Overall, the objective of this program is to decipher the remotely controlled translational landscape that mediates bone metastasis formation in breast cancer.

Preparing a pre-metastatic niche in the bone marrow through the remote control of translation by tumour-derived non-coding RNAs

Research/Job Area- Molecular and cellular biology

Location- Lyon, France

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Eligibility/Qualification–

PhD or MD/PhD in Biomedical Science Subject

• Hold a Ph.D. or MD/Ph.D. in a Biomedical Science Subject (or equivalent experience)
• Experience in Cancer Biology • Experience in Noncoding RNAs and/or Translation
• Experience in Molecular and/or Cellular Biology Techniques (including cell transduction and transfection, RT-qPCR, dual luciferase reporter assay, western blotting, flow cytometry, cell adhesion and cell migration/invasion assays, tumour spheroid assay, polysome profiling…) # Communication skills and personal effectiveness
• Effective communication skills, both written and verbal (experience of delivering presentations)
• Ability to analyze and solve problems with an appreciation of long-term implications
• Ability to work independently and effectively from the supervisors
• Ability to work in strong collaboration with the team and a second post-doctoral researcher

Desirable skills

• Experience in conducting experiments using Mouse Metastasis Models
• Experience in using computational programs for in silico analysis (RNA-seq data)

Job/Position Description- 

The two labs (LyOS and CRCL) are 10 minutes walking distance from each other in Lyon, France (https://en.lyon-france.com/)

Working language: French or English depending on the recruitment Working commitment

Gross Salary: Full-time position; 18 months / ≈30,000€ per annum (renewable once)

Closing date: September 30, 2020 / Starting date: between November 31, 2020 and February 22, 2021

How to Apply- 

Applicants should send a cover letter and a CV with two referees’ contacts to P. Clézardin and/or V. Marcel

• LyOS unit (www.lyos.fr): Professor Philippe Clézardin; philippe.clezardin@inserm.fr; p.clezardin@sheffield.ac.uk;

• CRCL unit, JJ Diaz’s lab (www.crcl.fr, twitter @crcl): Virginie Marcel; virginie.marcel@lyon.unicancer.fr

Last Date for Apply–  30 September 2020

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