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Post-Doctoral Research Associate at Liverpool School of Tropical Medicine (LSTM), UK

April 22, 2021

Designation/Position- Post-Doctoral Research Associate

Liverpool School of Tropical Medicine (LSTM), UK invites application for Post-Doctoral Research Associate from eligible and interested candidates

About- Founded in 1898 and the oldest of its kind in the world, the Liverpool School of Tropical Medicine (LSTM) is an internationally recognised centre of excellence for teaching and research in tropical diseases. Through the creation of effective links with governments, NGOs, private organisations and global institutions and by responding to the health needs of communities, LSTM aims to promote improved health, particularly for people of the less developed/resource poorest countries in the tropics and sub-tropics.

Research/Job Area- Molecular Biology, Genetics, Biochemistry or mosquito biology/entomology

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Location- Liverpool School of Tropical Medicine (LSTM), UK

Eligibility/Qualification–

Ideally, we are seeking a candidate that can demonstrate on their CV and application a combination of the below:

PhD (or similar experience) in Molecular Biology, Genetics, Biochemistry or mosquito biology/entomology
Experience in molecular biology
Experience in gene editing approaches
Strong record of preparing publications for specialist/ general science journals
Plan to develop own research ideas for grant applications
Experience of training staff in lab practices
Familiarity with CRISPR-Cas9 gene knock-out and knock-in
Proven ability to work in a team

Whilst not essential, having experience with gene drives, familiarity with experimental evolution, and experience working with mosquitoes or non-model insects would be advantageous to your application.

(For a full list of essential and desirable criteria please refer to the job description and person specification)

Job/Position Description-

An exciting opportunity has arisen for a post-doctoral scientist to join a group working on genetic vector control in the Department of Vector Biology. The role will develop novel approaches that investigate the possibility of synergizing two forms of vector control: insecticides and gene drive.

The main focus of your role will investigate regions of reduced diversity in the genome, arising as a result of selective sweeps or strong functional constraint, as targets for gene drive and also investigate the possibility of using CRISPR-based elements to understand the evolution of insecticide resistance. You will also be encouraged to develop new projects in related areas of interest, as time allows.

Key responsibilities include (but are not limited to):

Develop and expand genome editing approaches in mosquitoes.
- Use CRISPR technologies to edit mosquito genomes
- Build basic gene drives – self-copying elements that increase their frequency in the genome
Develop and expand systems for selecting insecticide resistance in vivo.
- Establish a screening protocol and selection regime for the emergence of insecticide resistance in mosquitoes
- Design caged population experiments to simulate the invasion of a gene drive element into a mosquito population.
Develop novel projects
- Generate ideas and data to support new project applications
- Apply for research grants/ fellowships in collaboration with PIs
Provide support and supervision to Ph.D. students and technical staff within the group.
- Create training material for, and provide training in molecular and analytical techniques to others in the lab
- Support Ph.D. students working on similar topics in the analysis of their data

How to Apply-

To apply for the position please follow this link(link is external) and upload your CV and a Covering Letter describing your relevant experience and the reason for your interest in the role.