Post Doc

Postdoc Position: IncRNAs in Leukemias- CEITEC MU, Czech Republic

October 26, 2020

Designation/Position- Postdoc Position: IncRNAs in Leukemias

Masaryk University, Czech Republic invites application for Postdoc Position: IncRNAs in Leukemias from eligible and interested candidates

About- Masaryk University is the second largest university in the Czech Republic, a member of the Compostela Group and the Utrecht Network. Founded in 1919 in Brno as the second Czech university, it now consists of nine faculties and 35,115 students. Postdoc Position: IncRNAs in Leukemias

Research/Job Area- Molecular biology, Oncology, Biochemistry, or similar field

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Location- Czech Republic

Eligibility/Qualification–

Your profile:

Motivated smart people that have the “drive” to work independently, but also willing to learn from other people in the lab and collaborate.
Candidates should have PhD degree (or expected within 3 months of applying) in Molecular biology, Oncology, Biochemistry, or similar field.
The Post-Doc position is for 2-4 years. Post-Doc position will start in 2020 (negotiable). Apply as soon as possible.
The position is NOT associated with any teaching obligations.
We welcome applications from all national (Czech) and international applicants

Job/Position Description-

We are looking for a motivated Post-Doc for a project funded by ERC Grant (Marek Mraz lab, www.ceitec.cz/mrazlab).

The project goal is to understand the role of noncoding RNAs in the regulation of microenvironmental interactions in B cell malignancies. The lab is deciphering novel mechanisms of BCR signaling regulation mediated by microenvironmental signals, CD20, p53, and the signals from T cells (Pavlasova et al. Blood, 2016; Pavlasova et al. Leukemia, 2018). We showed for the first time that non-coding RNAs, namely microRNAs (miRNAs), regulate the BCR signaling which opened an interesting field of research (Musilova et al. Blood, 2018; Mraz et al. Blood, 2014; Cerna et al. Leukemia, 2018). Now we would like to reveal the role of lncRNAs in BCR signaling and other microenvironmental interactions of leukemias.

We have identified candidate long-noncoding RNAs (lncRNAs) that might act as novel regulators of the crosstalk of BCR signaling/T-cell interactions/adhesion in B cell malignancies. This will be further investigated by the post-doctoral researcher using technics such as genome editing (CRISPRi), RNA sequencing, functional studies with various in vitro (primary cells and cell lines), and in vivo models. The research is also relevant for pre-clinical development of novel RNA-based therapeutic trials, and resistance mechanisms to BCR inhibitors.

WHAT DO WE OFFER:

project funded by the prestigious ERC grant = high risk and high gain, state-of-the-art instruments, stable funding, a competitive salary, collaboration with top experts in the field
You will work in a team of young investigators that challenge some long-standing problems in hematology (we have access to a large biobank of primary samples).
Interesting position in a dynamically expanding research institute
An attractive salary and benefits package (6 weeks of paid holiday, meal tickets, MU canteens, retirement contribution)
Background of a recognized and successful institution with supportive and international working environment
Environment promoting interdisciplinarity and intersectorality of research
In house core facilities
Support of administrative departments (including grant office service)
Support with the relocation process (welcome office service)

How to Apply-

TO APPLY:

To apply please send CV with two references and a full list of publications to the PI Marek Mraz:marek.mraz@email.cz (Subject: Post-Doc position).
Information about the laboratory at: http://mrazlab.ceitec.cz/positions.html